Differential neural representation of oral ethanol by central taste - 13 sensitive neurons in ethanol - preferring and genetically 14 heterogeneous rats
نویسندگان
چکیده
16 17 Christian H. Lemon, David M. Wilson, Susan M. Brasser 18 19 Dept. of Pharmacological and Physiological Science 20 St. Louis University School of Medicine 21 1402 South Grand Blvd 22 St. Louis, MO 63104 23 24 Dept. of Psychology 25 San Diego State University 26 5500 Campanile Dr 27 San Diego, CA 92182 28 29 30 Corresponding author: C.H. Lemon, [email protected] 31 32 Articles in PresS. J Neurophysiol (September 14, 2011). doi:10.1152/jn.00580.2011
منابع مشابه
Differential neural representation of oral ethanol by central taste-sensitive neurons in ethanol-preferring and genetically heterogeneous rats.
In randomly bred rats, orally applied ethanol stimulates neural substrates for appetitive sweet taste. To study associations between ethanol's oral sensory characteristics and genetically mediated ethanol preference, we made electrophysiological recordings of oral responses (spike density) by taste-sensitive nucleus tractus solitarii neurons in anesthetized selectively bred ethanol-preferring (...
متن کاملAlcohol activates a sucrose-responsive gustatory neural pathway.
A strong positive association exists between the ingestion of alcohol and sweet-tasting solutions. The neural mechanisms underlying this relationship are unknown, although recent data suggest that gustatory substrates are involved. Here, we examined the role of sweet taste receptors and central neural circuits for sugar taste in the gustatory processing of ethanol. Taste responses to ethanol (3...
متن کاملT1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference.
Elevated alcohol consumption is associated with enhanced preference for sweet substances across species and may be mediated by oral alcohol-induced activation of neurobiological substrates for sweet taste. Here, we directly examined the contribution of the T1r3 receptor protein, important for sweet taste detection in mammals, to ethanol intake and preference and the neural processing of ethanol...
متن کاملNeural representation of bitter taste in the nucleus of the solitary tract.
Based on the molecular findings that many bitter taste receptors (T2Rs) are expressed within the same receptor cells, it has been proposed that bitter taste is encoded by the activation of discrete neural elements. Here we examined how a variety of bitter stimuli are represented by neural activity in central gustatory neurons. Taste responses (spikes/s) evoked by bathing the tongue and palate w...
متن کاملGABA and glutamate overflow in the VTA and ventral pallidum of alcohol-preferring AA and alcohol-avoiding ANA rats after ethanol.
AIMS Earlier findings suggest that dopaminergic neurons are probably not critically involved in ethanol self-administration behavior and in the differential intake of ethanol by the alcohol-preferring AA (Alko Alcohol) and non-preferring ANA (Alko Non-Alcohol) rat lines selected for differential ethanol intake. The purpose of the present study was, therefore, to clarify the role of GABAergic an...
متن کامل